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Remote Controlled Theranostic Systems Lab

Invited researcher Gleb Borisovich Sukhorukov
Contract number
14.Z50.31.0004
Time span of the project
2014-2018

As of 30.01.2020

55
Number of staff members
53
scientific publications
13
Objects of intellectual property
General information

Name of the project: Remote controlled nanostructured systems for targeted delivery and diagnostics

Strategy for Scientific and Technological Development Priority Level: в


Goals and objectives

Research directions: Remote controlled nanostructured systems for targeted delivery and diagnostics

Project objective: Production of interactive nanoengineering systems (carriers) based on principles of assembly of nanostructured materials.


The practical value of the study

  • We have represented an in vitro and in vivo system for delivery of medications and biological materials via such physical impacts as magnetic field gradient and the optical tweezers technique.
  • Data has been obtained concerning biodistribution of medication delivery systems in the context of various methods of in vivo administration.
  • New hybrid carriers have been developed that can carry anti-tumor medications with intracellular degradation capabilities. The carriers are sensitive to ultrasound impact.
  • We have developed biosensors relying on giant Raman scattering and conducted in vitro tests of the sensors.
  • Our researchers have developed and investigated in vitro and/or in vivo methods of visualization of medication and biological solution delivery systems using bioluniographs, the photoacoustic method, and MRI imaging.
  • The Laboratory has developed a method of production of submicron-scale medication delivery systems and conducted in vitro and in vivo testing of these methods.
  • A device has been developed for visualization of micron-scale delivery systems in blood (in vitro and in vivo), at the same time an opportunity has been implemented for visualization and capture of molecules in magnetic field gradient.
  • We have developed methods of efficient non-invasive transdermal delivery of medications based on submicron-scale carriers with controlled release capability.
  • Our researchers have developed an encapsulated form of the lactoferrin protein that efficiently – using biocompatible microcontainers – releases protein in the small intestine.

Implemented results of research: Accumulated data concerning biodistributi of education delivery systems in the context of various methods o administration will be used to select a biologically active agent for subsequent encapsulation and pre-clinical tests.

Education and career development:

  • 3 doctoral dissertations and 11 candidate dissertations have been defended.
  • 55 young researchers from 14 higher education organizations have completed training at the Laboratory.
  • 17 education programs have been compiled (for the masters degree programs «Materials science and technology» and «Managing innovations in research-intense technologies», for the bachelor and master degree program «Electronics and nanoelectronics»).
  • 4 monographs and 5 textbooks have been published.

Organizational and structural changes: Unique costly equipment is used not only for collaborative usage by research groups at the Saratov State University but also for internships of young scientists from Russia and other countries. This allowed the Laboratory's team to win about 30 grants over the period between 2014 and 2018.

Other results:

  • The Laboratory has organized the 6th and the 7th International Conferences «Nanoparticles, nanostructured coatings and microcontainers: technology, properties, applications».
  • We have conducted the 2nd International School for Young Scientists «Nanostructured materials» within the «Nanoworkshop».

Collaborations:

  • Queen Mary University of London (United Kingdom), Max Planck Institute of Colloids and Interfaces (Germany), Charite University Hospital (Germany), Department of Biotechnology of the University of Ghent (Belgium), Institute of Materials Research and Engineering (Singapore), Medical Center of the University of Freiburg (Germany), Institute of Pediatric Oncology and Transplantology named after R. M. Gorbacheva (Russia), centers of the International Association of Russian-speaking Scientists – RASA in Kazan and Tomsk (Russia), Skolkovo Institute of Science and Technology (Russia), Institute of Bioorganic Chemistry named after Ovchinnikov and Shemyakin of the Russian Academy of Sciences (Russia): joint scientific research
  • Laboratory of Optical Theranostics (Russia): academic staff exchange, joint scientific research

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Voronin D., Sindeeva O., Kurochkin M., Mayorova O., Fedosov I., Semyachkina-Glushkovskaya O., Gorin D., Tuchin V., Sukhorukov G.
In Vitro and in Vivo Visualization and Trapping of Fluorescent Magnetic Microcapsules in a Bloodstream. ACS Аpplied Materials & Interfaces 9(8): 6885-6896 (2017).
Lengert E., Saveleva M., Abalymov A., Atkin V., Wuytens P.C., Kamyshinsky R., Vasiliev A.L., Gorin D.A., Sukhorukov G.B., Skirtach A.G., Parakhonskiy B.
Silver alginate hydrogel micro-and nano-containers for theranostics: synthesis, encapsulation, remote release and detection. ACS Applied Materials & Interfaces 9(26): 21949–21958 (2017).
KiIic E., Novoselova M., Lim S., Pyatayev N., Pinyaev S., Kulikov O., Sindeeva O., Mayorova O., Murney R, Antipina M., Haigh B., Sukhorukov G., Kiryukhin M.
Formulation for Oral Delivery of Lactoferrin Based on Bovine Serum Albumin and Tannic Acid Multilayer Microcapsules. Scientific Reports 7: 44159 (2017).
German S.V., Bratashov D.N., Navolokin N.A., Kozlova A.A., Lomova M.V., Novoselova M.V., Burilova E.A., Zyev V.V., Khlebtsov B.N., Amirov R.R., Bucharskaya A.B., Terentyuk G.S., Maslyakova G.N., Sukhorukov G.B., Gorin D.A.
In vitro and in vivo MRI visualization of nanocomposite biodegradable microcapsules with tunable contrast. Phys. Chem. Chem. Phys. (PCCP) 18: 32238–32246 (2016).
Korolovych V.F., Grishina O.A., Inozemtseva O.A., Selifonov A.V., Bratashov D.N., Suchkov S.G., Bulavin L.A., Glukhova O.E., Sukhorukov G.B., Gorin D.A.
Impact of high-frequency ultrasound on nanocomposite microcapsules: in silico and in situ visualization. Phys. Chem. Chem. Phys. (PCCP) 18: 2389–2397 (2016).
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