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Invited researcher Igor Rufailovich Nabiev
Contract number
11.G34.31.0050
Time span of the project
2011-2015

As of 30.01.2020

20
Number of staff members
167
scientific publications
23
Objects of intellectual property
General information

Name of the project: Hybrid nanobiomaterials with energy transfer qualities

Strategy for Scientific and Technological Development Priority Level: а


Goals and objectives

Research directions: Nanotechnologies and nanomedicine

Project objective: Research of energy transfer and ultra-fast processes at nano-level and applications of produced results in molecular diagnostics of illnesses and for creation of hybrid nanp-biosystems using effects of energy transfer from nanomaterials to biomaterials


The practical value of the study

  • We have developed a new type of diagnostic probes based on quantum dots that have better brightness, stability and biocompatibility as well as ultra-low physical dimensions. Using these probes we have created we have created diagnostic marks that are sensitive to specific markers of oncological conditions and a number of pathogens.
  • Our research has demonstrated that using developed diagnostic systems it is possible to numerically detect a set range of a big number of specific biomarkers with sensitivity and specificity.
  • We have studied two-photon processes in hybrid material based on semiconductor quantum dots and plasmonic nanostructures for applications in photovoltaics and optoelectronics.
  • We have developed methods for diagnostics and imaging of oncological conditions using resonance energy transfer in immunocomplexes single domain and full-scale antibodies.
  • We have created «graphene – quantum dots» hybrid 2D-structures with controlled optical and photoelectric qualities for applications in photovoltaics.
  • The Laboratory has created multifuncational stimulus-sensitive microcapsules and nanocrystals for early diagnostics and efficient treatment of lung cancer and breast cancer.

Implemented results of research:

  • Our researchers have conducted expert evaluation of diagnostic nanoprobes and suspension systems at the N.N. Blokhin National Medical Research Center for Oncology and the National Research Center of Epidemiology and Microbiology named after N. F. Gamalei of the Ministry of Health of the Russian Federation.
  • We have obtained 20 patents and industrial know-hows, created a series of working prototypes and conducted state testing.

Education and career development:

  • 1 doctoral dissertation, 8 candidate dissertations, 4 master dissertations have been defended.
  • Participation of promising students and postgraduates in the Laboratory's research.

Organizational and structural changes: The creation of a cluster of two laboratories («Laboratory of Nano-Bioengineering of the Moscow Engineering Physics Institute – MEPhI» and «International laboratory of hybrid photon nanomaterials of the Moscow Engineering Physics Institute - MEPhI») allowed to attract world-class scientists (prof. I. R. Nabiev, University of Reims (France), prof. Yu. P. Rakovich, International Physics Center (Spain)).

Other results: We have secured independent financing of the Laboratory after the end of state support within the mega-grant. This has been achieved by winning grants from Russian Science Foundation, Ministry of Health of the Russia, Ministry of Science and Education of Russia, Russian Foundation for Basic Research as well as international projects.

Collaborations:

  • University of Reims Champagne-Ardenne (France): joint research, scientific events, internships of employees, shared postgraduates
  • Max Planck Institute for Experimental Medicine (Germany), Medical University of Göttingen (Germany), University of Nantes (France), Trinity College Dublin (Ireland): joint research, scientific events, internships of students
  • Pohang University of Science and Technology (South Korea), Hosei University (Japan), Saint Petersburg University of Information Technologies, Mechanics and Optics - ITMO (Russia), N. N. Blokhin National Medical Research for Oncology (Russia), N. F. Gamalei National Research Center for Epidemiology   and Microbiology named after N. F. Gamalei (Russia): joint research and scientific events

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Bilan R., Ametzazurra A., Brazhnik K., Escorza S., Fernández D., Uríbarri M., Nabiev I., Sukhanova A.
Quantum-Dot-Based Suspension Microarray for Multiplex Detection of Lung Cancer Markers: Preclinical Validation and Comparison with the Luminex xMAP® System. Nature: Scientific Reports 7: 44668 (2017).
Vokhmintcev K.V., Samokhvalov P.S., Nabiev I.
Charge Transfer And Separation in Photoexcited Quantum Dot-Based Systems. Nano Today 11(2): 189–211 (2016).
Mochalov K., Efimov A., Bobrovsky A., Agapov I., Chistyakov A., Oleinikov V., Sukhanova A., Nabiev I.
Combined Scanning Probe Nanotomography and Optical Microspectroscopy: a Correlative Technique for 3D Characterization of Nanomaterials. ACS NANO 7: 8953 (2013).
Bobrovsky A., Mochalov K., Oleinikov V., Sukhanova A., Prudnikau A., Artemyev M., Shibaev V., Nabiev I.
Optically and Electrically Controlled Circularly Polarized Emission from Cholesteric Liquid Crystal Materials Doped with Semiconductor Quantum Dots. Advanced Materials 24(46): 6216–6222 (2012).
Sukhanova A., Even-Desrumeaux K., Kisserli A., Tabary T., Reveil B., Millot J.M., Chames P., Baty D., Artemyev M., Oleinikov V.A., Pluot M., Cohen J.H.M., Nabiev I.
Oriented Conjugates Single-Domain Antibodies and Quantum Dots: Toward New Generation of Ultra-Small Diagnostic Nanoprobes. Nanomedicine: NBM 8(4): 516–525 (2012).
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