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Invited researcher Rudolf Valenta
Contract number
14.W03.31.0024
Time span of the project
2018-2020

As of 15.02.2021

19
Number of staff members
20
scientific publications
2
Objects of intellectual property
General information
Name of the project: From immune detection of major allergen of birch tree pollen Bet v 1 to specific diagnostics, therapy and prevention strategies for allergy caused by birch tree pollen

Strategy for Scientific and Technological Development Priority Level: в

Goals and objectives
Research directions: Molecular allergology

Project objective: Research and characterization of allergic immune response against major allergen of birch tree pollen Bet v 1 in Russian population ti develop a diagnostic test-system and identifying recombinant natural allergens, antibodies and synthetic peptides for treatment and prevention of birch tree pollen allergy

The practical value of the study
The recognition profiles of IgE and IgG antibodies in patients with allergy to birch pollen were determined, Bet v 1-specific T-cells were mapped and the cytokine response was studied. A hypoallergenic vaccine based on recombinant proteins containing Bet v 1 peptides and a non-allergenic carrier protein has been characterized, their allergenic activity and the ability to induce the production of protective IgG antibodies in experimental in vitro and in vivo models have been studied. A prototype of a recombinant vaccine based on Bet v 1 with specific activity has been created.

Education and career development:

In 2018, a leading scientist and research team members took part and made oral and poster presentations at the Congress of the European Academy of Allergology and Clinical Immunology (EAACI Congress 2018), Munich, Germany; in the International Forum "Uzbekistan 2035", Tashkent, Uzbekistan; in the Conference of Children's Allergology "Friso", Petrozavodsk, Russia; at the 2nd Academy of Autoimmunity, St. Petersburg, Russia; at the fourth scientific-practical school-conference "Allergology and Clinical Immunology", Sochi, Russia. In addition, the 1st Moscow Conference on Molecular Allergology (MMAM-2018) was organized on November 27, 2018 in Moscow, Russia.

In 2019, a leading scientist and research team members took part and made oral and poster presentations at the Congress of the European Academy of Allergology and Clinical Immunology (EAACI Congress 2019), Lisbon, Portugal; at the Joint Immunological Forum, Novosibirsk, Russia; at the 3rd International Meeting on Immunity Regulation "Immune activation, effector functions and immune tolerance with a special focus on autoimmunity", Davos, Switzerland; at the Joint Scientific Forum, VI Congress of CIS Physiologists, VI Congress of Russian Biochemists, IX Russian Symposium "Proteins and Peptides", Sochi, Russia; at the Congress of the International Allergy Society, Lyon, France; in the International Conference held by the Primorsky Regional Branch of the Russian Association of Allergists and Clinical Immunologists (RAACI) in conjunction with the Primorsky Branch of the Union of Pediatricians of Russia, Vladivostok, Russia; in the 17th Immunology Congress of the International Union of Immunological Societies (IUIS), Beijing, China; at the International Symposium on Molecular Allergology (ISMA 2019), Amsterdam, The Netherlands. The 2nd Moscow Conference on Molecular Allergology (MMAM-2019) was also organized on November 19, 2019 in Moscow, Russia.

In 2020, the leading scientist and research team members took part and made scientific reports on the topic of the Megagrant at the XXXVII Scientific and Practical Conference "Rakhmanov Readings": "Modern Dermatovenereology and Interdisciplinary Relations" (January 30-31, 2020, Moscow, Russia), at XXII Congress of Russian Pediatricians with international participation "Actual Problems of Pediatrics" (February 21-23, 2020, Moscow, Russia), at the Digital Congress of the European Academy of Allergology and Clinical Immunology (EAACI Digital Congress 2020) (June 6-8, 2020, London, Great Britain) and at the 16th RAACI International Interdisciplinary Congress on Allergology and Immunology online (June 24–27, 2020, Moscow, Russia). As part of the Megagrant, an online conference "Allergies and Immunodeficiency States in the Context of the COVID-19 Pandemic" was successfully held (May 21, 2020, Moscow, Russia). Organized 1st Congress on Molecular Allergology - MAC 2020 (December 1-2, 2020, Moscow).

Organizational and structural changes:

To conduct scientific research under the leadership of leading scientist at the Federal State Budgetary Institution National Research Center "Institute of Immunology" of the Federal Medical and Biological Agency of Russia (contract No. 14.W03.31.0024 dated February 1, 2018) and to solve the tasks set within the framework of the researc on the basis of the Institute of Immunology was founded the laboratory of Molecular Allergology (order 18 of 01/26/18). Additional equipment at the expense of funds allocated for research. Thus, to date, 62 units of high-tech laboratory equipment have been assigned to the laboratory of molecular allergology, which made it possible to solve all the set research tasks.

Collaborations:

Throughout the entire period of the research, members of the research team and graduate students underwent retraining courses at the Vienna Medical University in research areas within the framework of grant 14.W03.31.0024.

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Elisyutina O, Lupinek C, Fedenko E, Litovkina A, Smolnikov E, Ilina N, Kudlay D, Shilovskiy I, Valenta R, Khaitov M.
IgE-reactivity profiles to allergen molecules in Russian children with and without symptoms of allergy revealed by micro-array analysis. Pediatr Allergy Immunol. 2021 Feb;32(2):251-263. doi: 10.1111/pai.13354. Epub 2020 Oct 4. PMID: 32869350; PMCID: PMC7891667. (Q1)
Karsonova A, Riabova K, Villazala-Merino S, Campana R, Niederberger V, Eckl-Dorna J, Fröschl R, Perkmann T, Zhernov YV, Elisyutina OG, Fedenko ES, Khaitov MR, Fomina D, Beltiukov E, van Hage M, Grönlund H, Valenta R, Karaulov A, Curin M.
Highly sensitive ELISA-based assay for quantification of allergen-specific IgE antibody levels. Allergy. 2020 Apr 17. doi: 10.1111/all.14325. [Epub ahead of print] (Q1)
Nikonova A, Khaitov M, Jackson DJ, Traub S, Trujillo-Torralbo MB, Kudlay DA, Dvornikov AS, Del-Rosario A, Valenta R, Stanciu LA, Khaitov R, Johnston SL.
M1-like macrophages are potent producers of anti-viral interferons and M1-associated markerpositive lung macrophages are decreased during rhinovirus-induced asthma exacerbations. EBioMedicine. 2020 Apr;54:102734. doi: 10.1016/j.ebiom.2020.102734. Epub 2020 Apr 9. (Q1)
Dorofeeva Y, Shilovskiy I, Tulaeva I, Focke-Tejkl M, Flicker S, Kudlay D, Khaitov M, Karsonova A, Riabova K, Karaulov A, Khanferyan R, Pickl WF, Wekerle T, Valenta R.
Past, presence, and future of allergen immunotherapy vaccines. Allergy. 2020 Apr 6. doi: 10.1111/all.14300. Online ahead of print. (Q1)
Tulaeva I, Kratzer B, Campana R, Curin M, van Hage M, Karsonova A, Riabova K, Karaulov A, Khaitov M, Pickl WF, Valenta R.
Preventive allergen-specific vaccination against allergy: Mission possible? Front. Immunol., 07 July 2020 https://doi.org/10.3389/fimmu.2020.01368 (Q1)
Elisyutina O, Fedenko E, Campana R, Litovkina A, Ilina N, Kudlay D, Egorenkov E, Smirnov V, Valenta R, Lupinek C, Khaitov M.
Bet v 1- specific IgE levels and PR-10 reactivity discriminate silent sensitization from phenotypes of birch allergy. Allergy. 2019 Dec;74(12):2525-2528 Q1
Linhart B, Freidl R, Elisyutina O, Khaitov M, Karaulov A, Valenta R.
Molecular Approaches for Diagnosis, Therapy and Prevention of Cow´s Milk Allergy. Nutrients. 2019 Jun 29;11(7). pii: E1492. doi: 10.3390/nu11071492 Q1
Campana R, Marth K, Zieglmayer P, Weber M, Lupinek C, Zhernov Y, Elisyutina O, Khaitov M, Rigler E, Westritschnig K, Berger U, Wolkersdorfer M, Horak F Jr, Horak F, Valenta R.
Vaccination of nonallergic individuals with recombinant hypoallergenic fragments of birch pollen allergen Bet v 1: Safety, effects, and mechanisms. J Allergy Clin Immunol. 2019 Mar;143(3):1258-1261. doi: 10.1016/j.jaci.2018.11.011 Q1
Eckl-Dorna J, Villazala-Merino S, Campion NJ, Byazrova M, Filatov A, Kudlay D, Karsonova A, Riabova K, Khaitov M, Karaulov A, Niederberger-Leppin V, Valenta R.
Tracing IgE-Producing Cells in Allergic Patients. Cells. 2019 Aug 28;8(9). pii: E994. doi: 10.3390/cells8090994 Q1
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