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Invited researcher Marcus Conrad
Contract number
Time span of the project

As of 30.01.2020

General information

Name of the project: Targeted activation of ferroptosis, a new type of of cell death, as a strategy for therapy of obstinate and metastasizing tumors.

Strategy for Scientific and Technological Development Priority Level: в

Goals and objectives

Recent findings revealed that “therapy-persister” and mesenchymal cancer cells emerge to be highly sensitive to ferroptosis, a quite recently described form of regulated non-apoptotic cell death modality marked by iron-dependent lipid peroxidation. Current studies of our laboratory are focused on investigating the molecular mechanisms of ferroptosis in the context of tumorigenesis, particularly in the sensitization and execution of ferroptosis in different cancer models. Our studies aim to provide novel data for the development of new ferroptosis-inducing therapeutics to combat difficult-to-treat and metastatic tumors.

The practical value of the study

1)      Investigation of the translational potential of the ferroptosis activation in the context of different tumor models.

2)      Screening and development of novel low-molecular ferroptosis inducers as potential agents for anti-tumor therapy.

Expected results:

Molecular components of the ferroptosis cascade, including its activators and inhibitors, and mechanisms of ferroptosis regulation will be identified and characterized. Data on the efficacy of low molecular synthetic ferroptosis inducers to prevent the growth and spread of different tumors will also be provided. Results obtained herein will thus expand our knowledge on the implementation of ferroptosis induction as a novel anticancer strategy.

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