Laboratory of Experimental Oncology

Name of the project: Targeted activation of ferroptosis, a new type of of cell death, as a strategy for therapy of obstinate and metastasizing tumors.

Strategy for Scientific and Technological Development Priority Level: в

Recent findings revealed that “therapy-persister” and mesenchymal cancer cells emerge to be highly sensitive to ferroptosis, a quite recently described form of regulated non-apoptotic cell death modality marked by iron-dependent lipid peroxidation. Current studies of our laboratory are focused on investigating the molecular mechanisms of ferroptosis in the context of tumorigenesis, particularly in the sensitization and execution of ferroptosis in different cancer models. Our studies aim to provide novel data for the development of new ferroptosis-inducing therapeutics to combat difficult-to-treat and metastatic tumors.