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Invited researcher Hans-Uwe Simon
Time span of the project
2021-2023
General information
Name of the project: mTOR1 regulation in the process of mitochondrial metabolism: the impact on inflammation and carcinogenesis

Strategy for Scientific and Technological Development Priority Level: в
Goals and objectives

The goal of this project is the study of the impact of metabolic reprogramming of mitochondria on the function of macrophage in the immune response to cancer cells in carcinogenesis, as well as to parasitic infection in translational medicine. In relation to this, the following tasks have been set:

  1. To research the role of mitochondria in metabolic reprogramming of macrophage in vivo;
  2. To study the impact of mitochondrial adaptations on the functional properties and the polarisation of macrophage both in vitro and in vivo;
  3. To forecast the composition of a hypothetical signalling pathway binding mitochondria and mTORC1 activity;
  4. To determine a possible role of mitochondrial adaptations in metabolic and functional rearrangements in cancer cells using corresponding animal models.

The supposed new connection between mitochondria and mTORC1 activity is a general regulatory mechanism that is necessary for the functional adaptation of cells. In this project, the focus is laid on immune reactions and oncogenesis.

The practical value of the study

Projected research results: 

A successful completion of the project should produce new theoretical strategies for the battle against chronic inflammatory diseases and cancer that will be protected by corresponding Russian and internation patents. The results obtained during the implementation of this project will allow to transition to personalised medicine, hi-tech healthcare, health-preserving technologies, including the rational use of medications in the Russian Federation. Apart from that, the produced results can lead to a change in the existing paradigm of the functions of mitochondria and their role in carcinogenesis and the immune response in particular. The results of this will be reflected in journals with high impact factor (IF>10).

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