We use cookies.
By using the site, you agree to our Privacy Policy.

Invited researcher Liang Xing-Ji
Time span of the project
2021-2023
General information

The Laboratory's work will be aimed at the development of personalised solutions in the field of regenerative medicine and nano-medicine, while the expected results will contribute significantly to the investigation of top priority problems of these areas in the coming years.

Name of the project: The development of smart nano-technologies for osteoarthritis treatment

Strategy for Scientific and Technological Development Priority Level: в
Goals and objectives

Osteoarthritis (OA) is one of the most traumatic socially significant diseases that reduce the quality of life and lead to premature loss of working capacity. Apart from the traditional approaches to OA treatment (such as local and intra-articular administration of drugs and biomaterials), innovative treatment methods are also used that employ, for example, laser radiation or the injection of autologous cellular spheroids. However, these technologies require special conditions and the usage of additional competencies by medical personnel, which significantly impedes their large-scale introduction into practice. The main goal of the proposed project is the development of a smart nano-           technology for OA treatment based on the use of matrix-bound vesicules (MBVs) and their functionalisation by magnetic nano-particles as activators of the anti-inflammatory phenotype of macro-phages and tissue remodelling thanks to the unique lipid profile of their membranes. In trauma care, magnetic physiotherapy is widely used, while its combined use with the developed nano-systems will allow for a more targeted impact on damaged tissues and immune cells. The unique and broad competencies of Professor Liang Xing-Jie in the field of formation of «smart» nano-systems for targeted delivery of biologically active substances and magnetic nanoparticles will allow to develop an original approach to efficient modification of MBVs and their control. We will additionally engage the groups lead by professor Stephen Badylak (University of Pittsburgh), a worldwide leader in the field of MBV research and professor Elizaveta Kon (Humanitas University), a worldwide leader in the field of innovative approaches in orthopaedics.

To achieve these goals, the following tasks have been set for the laboratory:

  • The development of an efficient method of amplification of accumulation and emission of MBVs;
  • The determination of the composition of MBVs, including the analysis of the lipid and protein profile, RNA sequencing;
  • The detection of molecular features of the interaction between MBVs and immune cells;
  • The development of an automated complex using a three-dimensional ultra-sound system and ultra-precise neural networks;
  • The modification of their surfaces to ensure targeted delivery to the damaged region of cartilaginous tissue and phenotype switching of immune cells;
  • The development of a method of their control by an external magnetic field;
  • The determination of the affinity of the developed nano-system, its safety and efficiency in an animal model (rats, rams/mini pigs).

Other laboratories and scientists
Hosting organization
Field of studies
City
Invited researcher
Time span of the project
Laboratory of Super-elastic Bio-interfaces

National Research Tomsk State University

Medical biotechnologies

Tomsk

Volinsky Alexei

USA

2021-2023

Laboratory of Laser Molecular Imaging and Machine Learning

National Research Tomsk State University

Medical biotechnologies

Tomsk

Igor Konstantinovich Lednev

Russia

2021-2023

Laboratory of Molecular Allergology

Institute of Immunology of the Federal Biomedical Agency of Russia

Medical biotechnologies

Moscow

Rudolf Valenta

Austria

2018-2020