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Laboratory for Biotechnology of New Materials

Invited researcher Anthony John Sinskey
Contract number
11.G34.31.0013
Time span of the project
2010-2014
Head of the laboratory

As of 30.01.2020

7
Number of staff members
113
scientific publications
19
Objects of intellectual property
General information

Name of the project:   Biotechnology of new materials

Strategy for Scientific and Technological Development Priority Level: в


Goals and objectives

Research directions: Synthesis and study of biomaterials, developing products for biomedicine

Project objective: Creating a scientific basis for application of biodestructible polymers of set structure in biomedical technologies and experimental justification of their application


The practical value of the study

  • We have research laws of microbe growth and metabolism of cellular nanomolecules.
  • The Laboratory has developed biotechnologies for synthesis of destructible biopolymers of various structure with a wide range of qualities.
  • Our researchers have obtained fundamental knowledge about processing of destructible biopolymers by soluble technologies, contact pressing, extrusion, electrospinning etc.
  • We have constructed a pioneering family of specialized products for medicine (micro- and nanocarriers of medications, scaffolds of functioning cells, implants and endoprosthetics) that are efficient for reconstructive technologies.

Implemented results of research:

  • We have certified the created R&D prototypes with the Federal Agency on Technical Regulation and Metrology: suturing resorbable mono-threads,biocompatible coatings of vessel stents, endobiliary stent, bone-plastic materials, biotechnological dermal equivalents. They have been positively assessed in experimental pre-clinical trials.
  • Our laboratory has created the basis for state registration of products and conducting clinical trials necessary for implementing the products into clinical practice.

Education and career development:

  • 3 doctoral dissertations, 10 candidate dissertations, and 60 masters and bachelors dissertations have been defended.
  • Facilitators of the project completed internships at MIT (USA), University of Cádiz (Spain), Institute of Chemical Biology and Fundamental Medicine of the Siberian Department of the Russian Academy of Sciences (Russia), Irkutsk Anti-Plague Institute (Russia), Kazan Federal University (Russia), and the «Mettker Toledo CIS».
  • 17 researchers from universities of the Krasnoyarsk region have completed «Biotechnologies and organizing efficient work of engineering and technological services in a modern medical center» internships at the Laboratory.
  • We have prepared masters programs «Reconstructive materials», «Managing medical and biological systems and complexes», «Fundamental and applied biology», career enhancement program «Technical maintenance of medical equipment», education programs for additional professional training «Engineering systems of life support of buildings of medical complex».
  • We have published an electronic textbook «Modern equipment and methods of biological systems research. A big case study» edited by T. G. Volova and A.J. Sinskey fir students of universities.

Organizational and structural changes:

We have created a structure for research and practice that includes including prototype production for biopolymers and specialized products with a complete cycle of research facilities for physical, chemical, mechanical and biological qualities.

 Other results:

We have conducted 3 international conferences with youth schools «Biotechnology of new materials and environments» (2011), «Biotechnology of new materials – environments – quality of life» (2016, 2017).

Collaborations:

  • Krasnoyarsk State Medical University(Russia), Sklifosovsky Research Institute of Emergency Medicine (Russia), Institute of Biophysics of the Siberian Department of the Russian Academy of Science (Russia), National Research Tomsk Polytechnic University (Russia), Belgorod State University (Russia), Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB (Germany), Inorganic Chemistry and Center for Nanointegration Duisburg-Essen, University of Duisburg-Essen (Germany): joint research
  • Moscow State University (Russia), D. Mendeleyev University of Chemical Technology of Russia (Russia): joint conferences, scientific publications, student exchange
  • Skryabin Institute of Biochemistry and Physiology of Microorganisms of the Russian Academy of Sciences (Russia), Institute of Biophysics of the Siberian Department of the Russian Academy of Sciences (Russia), Biomaten Center of the Middle East Technical University (Turkey): joint scientific publications and lectures
  • Privolzhkiy Federal Research Medical Center of the Ministry of Health of Russia: experimental clinical trials
  • Krasnoyarsk State Medical University(Russia): joint testing of production prototype
  • Mahatma Gandhi University (India): collaboration in the field of green chemistry and green biomaterials
  • State Regional Center for Standardization, Methodology and Testing of the Krasnoyarsk Region (Russia): certification of polymers and polymer products


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Volova T., Kiselev E., Shishatskaya E., Zhila N., Boyandin A., Syrvacheva D., Vinogradova O., Kalacheva G., Vasiliev A., Peterson I.
Cell growth and PHA accumulation from CO2 and H2 of a hydrogen-oxidizing bacterium, Cupriavidus eutrophus В-10646. Bioresource Technology 146: 215–222 (2013)
Volova T., Zhila N., Kalacheva G., Brigham C., Sinskey A. J.
The effects of the intracellular poly(3-hydroxybutyrate) reserves on physiological-biochemical properties and growth of Ralstonia eutropha. Research in Microbiology 164 (2): 164–171 (2013)
Boyandin A.N., Prudnikova S.V., Karpov V.A., Ivonin V.N., Đỗ Ngọc Lanh, Nguyễn Thị Hoài, Lê Thị Mỹ Hiệp, Filipenko M.L., Volova T.G., Gitelson I.I.
Microbial degradation of polyhydroxyalkanoates in tropical soils. International Biodeterioration & Biodegradation 83: 77–84 (2013)
Murueva A.V., Shishatskaya E.I., Kuzmina A.M., Volova T.G., Sinskey A.J.
Microparticles prepared from biodegradable polyhydroxyalkanoates as matrix for encapsulation of cytostatic drug. Journal of Materials Science: Materials in Medicine 24(8): 1905–1915 (2013)
Volova T.G., Kiselev E.G., Vinogradova O.N., Nikolaeva E.D., Chistyakov A.A., Sukovatyi A.G., Shishatskaya E.I.
A glucose-utilizing strain, Сupriavidus eutrophus В-10646: growth kinetics, characterization and synthesis of multicomponent PHAs. PLoS ONE 9(2): 1–15 (2014)
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