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Research Laboratory for the Mechanics of Bio-compatible Materials and Devices

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General information

The project is aimed at the research and analysis of physical and mechanical properties, the study of the mechanical behaviour, and biological interactions as well as at the development of methods of monitoring of bio-compatible materials suitable for the production of implants, scaffolds for tissue engineering, stents, and other bio-medical devices.

Name of the project: Mechanics of bio-compatible materials and devices

Strategy for Scientific and Technological Development Priority Level: а

Goals and objectives

The objective of the research is the creation of a scientific basis for the development of new classes of products for patient-oriented medicine relying on bio-compatible materials with optimal physical, mechanical, and biological characteristics produced using additive technologies. Among the goals of the projects we envision:

  1. The development of methods and approaches for the description of the physical and mechanical behaviour and the assessment of properties of bio-materials with controllable micro-structure created by means of additive technologies;
  2. The development of methods of solving problems of optimisation of the topological structure, mechanical, transportation, and biological properties of bio-materials with consideration to bio-compatibility requirements, parameters of loading, and the environment;
  3. The study of the processes of biodegradation of materials and the growth of tissues in a biological environment;
  4. The creation of models of the mechanical behaviour of living tissues, the processes of the interaction between living and non-living matter during the integration of biomaterials and devices based on them with the human body;
  5. The creation of methods for monitoring of the mechanical state of bio-materials and devices based on them.

The practical value of the study
Projected research results: 

  • On the basis of the results of the implementation of the project, new approaches will be developed for the quantitative and experimental research of changes of the properties of bio-materials and bio-medical products during their interactions with living tissues; multi-scale models will be created to describe the deformation behaviour and destruction of bio-materials and products based on them with respect to the experimental identification of their physical, mechanical, and morphological characteristics; new methodological foundations for the experimental research of the mechanical behaviour of bio-materials, structural elements of bio-medical products at a characteristic scale level as well as of soft tissues; methodologies and approaches to the creation of bio-materials and bio-medical products on the basis of the FDM and SLM additive technologies will be modified;
  • To implement the concept of monitoring of the deformation state of bio-medical products, we will refine methodologies of measurement of temperatures and deformations using fibre optic detectors installed into bio-materials produced by 3D printing;
  • To research the interaction of bio-compatible materials with living tissue and the physiological environment, we will develop numerical models of tissue, models of its interaction with installed artificial implants as well as approaches to the experimental quantification of parameters of these models;
  • We will collect new experimental data on the bio-compatibility, bio-degradation, and the bio-mechanical properties of metallic and polymer materials prone to the impact of physiological environments;
  • The developed approaches will be used for the analysis, the optimisation of the structure and the properties of two classes of bio-medical devices – porous scaffolds for tissue engineering, as well as of endovascular stents;
  • We will develop a methodology for the determination of the optimal structure of scaffolds and stents for their use in specific applications accounting for data on the behaviour of bio-materials and products under various types of loads and the impact of aggressive environments.

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