Laboratory for Remotely Controlled Systems for Theranostics
This laboratory was established as part of a scientific research project supported with a monetary grant awarded by the Government of the Russian Federation under a grant competition designed to provide governmental support to scientific research projects implemented under the supervision of the world's leading scientists at Russian institutions of higher learning (Resolution of the RF Government No.220 of April 9, 2010).
Grant Agreement No.:
Name of the institution of higher learning:
Saratov State University named after N. G. Chernyshevsky
Fields of scientific research:
To conduct research in remotely controlled nanostructured systems for targeted delivery and diagnostics, as well as to use research results in education and innovations.
To engineer interactive systems (carriers) based on nanostructured materials that can be used to perform remotely controlled delivery of biologically active substances and assess health condition. Unlike many other research teams working on the same problem, this laboratory is developing a fundamentally new approach. The scientists are using physical methods to monitor the movement of objects, remotely unpack them and release medications. In order for a capsule to do its job, e.g. collect a toxic substance and then dissolve or exit the organism. It performs all these actions using remote control tools, such as electromagnetic radiation of varying ranges, radio frequency emissions, X-ray radiation, magnetic field or ultrasound. Ideally, nanoparticles are controlled similarly to how a TV set is controlled using a remote control unit. In order to achieve that, it is necessary to meet several conditions:
- first, create micron-sized or even smaller carriers (smaller than a cell);
- second, they must be made visible;
- third, the carriers must contain requisite substances inside themselves.
These carriers, filled with biologically active substances, are delivered to the source of pathology in measured amounts and at a steady pace. The scientists are developing capsules based on polymers and using synthesis on the surface of colloidal particles with assistance of special matrixes known as simplants. These particles can be made to look like hollow spheres or disks. The laboratory staff perform physical and chemical assembly of polymers: they create a particle containing requisite substance inside and implant nanoparticles into its outer shell. The outer shell protects the active substance inside the particle enabling it to release the substance at the requisite place and at the requisite time.
Anticipated results of the project:
The project seeks to develop a technology enabling delivery of medications in strictly measured amounts, at the right time and at the right place where the medication is truly required. These systems will be based on nanostructured micro-objects whose surface can be used as a biosensor. These micro-objects will not only signal of any problems in an organism, but they will also operatively fix those problems by releasing the medication contained inside.
Full Name:Sukhorukov Gleb Borisovich
Link to the scientist's profile
Academic degree and title:
Doctoral degree in Physics and Mathematics, Professor
Job Title:Professor, Chair in Biopolymers and Bio-organic Interfaces, School of Engineering and Materials Science/Department of Materials, Queen Mary University of London (UK)
Field of scientific interests:
Physics and biochemistry at the submicron scale. Creation of multifunctional colloidal particles and capsules. Development of remotely controlled delivery systems.
The leading scientist was the first to demonstrate the possibility of creating a polymer shell on colloidal micro-particles using consecutive polyelectrolyte absorption, as well the possibility of using this method for creating microcapsules and encapsulation of various substances. He has authored and co-authored more than 200 articles and 12 patents.
One of the world's Top-10 most famous scientists of Russian descent according to "Forbes" magazine (2011). Since 2007, he has been a visiting professor at the Institute of Materials Research and Engineering of the Singapore Agency for Science, Technology and Research. He founded and successfully managed the "Multifunctional Nanostructured Polymer Microcapsules" working group at the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany. Serves as a reviewer at more than 10 highly referenced international journals. He coordinated and oversaw a large number of research projects, including EU-sponsored projects. He is the recipient of a Sofia Kovalevskaya Grant (issued by the Alexander Humboldt Foundation and the Ministry of education and research of Germany in 2001 – 2005).