Laboratory for the Study of Molecular Mechanisms of Neurodegeneration and Aging
This laboratory was established as part of a scientific research project supported with a monetary grant awarded by the Government of the Russian Federation under a grant competition designed to provide governmental support to scientific research projects implemented under the supervision of the world's leading scientists at Russian institutions of higher learning (Resolution of the RF Government No.220 of April 9, 2010).
Link to the official website - missing
Grant Agreement No.:
Name of the institution of higher learning:
The Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences (IMB RAS)
Fields of scientific research:
To establish a laboratory capable of becoming a large international research center specializing in the field of molecular mechanisms responsible for neurodegeneration and aging.
- To implement a new approach based on identifying the impact of metabolic processes occurring in a bacterial cell upon the longevity of the host organism, C. elegans dematode.
- To verify the action mechanism of bacterial regulators of transcription (RNA-polymerase, Rho-factor, and sensory RNA) whose expression may affect the longevity of nematodes.
- To look for and identify E.coli genes that can modulate the longevity of C.elegans and to engineer strains in possession of probiotic properties by deactivating "harmful" genes and intensifying expression of "useful" genes that extend the longevity of C. elegans.
- To test AICAR and other geroprotectors on account of their effectiveness, toxicity and other parameters required for their potential application in humans.
- To investigate protective action of HSP70 when neural cell cultures (neuroblasts) are acted upon by pathogenic peptides (iso-A beta).
Anticipated results of the project:
The project will determine the molecular mechanism connecting zinc ions with the pathogenic mutant H6R-isoform of beta-amyloid (H6R-А beta) and facilitate the conduct of a quantitative analysis of the composition of brain proteins in 5XFAD mice engrafted with HSP70 and other modulators and their comparison with the control group.
The project will research the activity and composition of proteasomes using the mice version of Alzheimer's disease and conduct quantitative proteomic research of various brain compartments of old mice engrafted with HSP70 and other geroprotectors and comparison of the outcomes with the control group of animals.
The principal outcome of the project will be represented by a better understanding of the molecular mechanisms of aging and neurodegeneration, as well as identification and testing of metabolites and proteins acting as geroprotectors in various model organisms.
The project entails participation of a number of young researchers. The average age of the laboratory staff members is 43 years, and the share of young scientists within the project staff is 35%.
Full Name: Nudler Evgeny Aleksandrovich
Link to the scientist's profile
Academic degree and title:
Head of the Laboratory and Julie Wilson Anderson Professor at the Department of Biochemistry
and Molecular Pharmacology, Medical School, New York University (USA)
Field of scientific interests:
Aging of biological organisms, gene activity regulation, sensory RNA mechanisms, response of biological organisms to stress, and properties of the so-called "gas carriers".
The leading scientist is a member of various professional research communities, such as the American Association for Science Development, New York Academy of Sciences, American Microbiological Society, etc. He is a tenured professor at New York University where he oversees a laboratory at the New York University Medical Center. Professor Nudler is a recipient of numerous prestigious awards recognizing his contribution to molecular and cellular biology.
He is a Howard Hughes Medical Institute Researcher.