Laboratory for the Study of Brain Stem Cells
This laboratory was established as part of a scientific research project supported with a monetary grant awarded by the Government of the Russian Federation under a grant competition designed to provide governmental support to scientific research projects implemented under the supervision of the world's leading scientists at Russian institutions of higher learning (Resolution of the RF Government No.220 of April 9, 2010).
Grant Agreement No.:
Name of the institution of higher learning:
Moscow Institute of Physics and Technology (State University)
Fields of scientific research:
To find solutions for some of the fundamental problems associated with the origin and evolution of modern man in Northern Asia.
To investigate regulation mechanisms of stem cells, the processes of their modification as they age or are affected by pharmaceuticals; to identify the reasons why sometimes stem cells divide and other times refuse to do so; to find out why stem cells sometimes divide symmetrically and other times – asymmetrically; to study the processes associated with the dying of stem cells, as well as their transformation into other types of cells.
The project will help create a new experimental platform for isolation and study of adult brain stem cells. The project will help design new methods of three-dimensional visualization of stem and dividing cells of the brain. The project will design a method of triple marking of dividing stem cells that will dramatically enhance the extent of precision when analyzing multiple mutually transforming populations of brain stem cells. The scientists will identify the targets of some of the most important neurogenesis regulators in adult brain. They will determine the effect of small radiation doses on adult brain stem cells and behavioural reactions associated therewith. The project has already shown that a reduced calorie diet helps increase the number of active stem cells in an aging brain. The scientists have developed general methods that are used to look for chemical compounds affecting brain stem cells, and have tested the first such compounds identified. The scientists have identified a new type of ovary stem cells that repair ovary tissues following ovulation, which, however, are also capable of transforming themselves into cancerous cells causing ovarian tumours. The scientists have obtained genetically modified drosophila lines that are capable of responding to extremely small radiation doses. These lines can be used as extremely sensitive radiation sensors. The scientists have developed genetically encoded cellular redox activity sensors characterized with enhanced sensitivity.
The project has helped develop genetically encoded cellular redox activity sensors that possess various fluorescence parameters. Such an expanded gamut helps conduct multiplex monitoring of redox-signalization in stem cells.
The scientists have designed a computer model of the cascade of changes undergone by stem cells and their offspring that takes into account reproduction, death, and differentiation of cells and mutual transformation of different cell populations. This model can be used for many other systems characterised by complex kinetics of reproduction and mutual transformation of different cell types, cell populations and populations of organisms.
Full Name: Enikolopov Grigori Nikolaevich
Academic degree and title:
Associate Professor in the field "Molecular Biology"
Group Leader, professor, Cold Spring Harbour Laboratory (USA), Head of the Laboratory for the Study of Brain Stem Cells at the Moscow Institute of Physics and Technology (Russia), member of the study programs on neurobiology, genetics, molecular biology and pharmacology at the Stony Brook University (USA).
Fields of scientific interests:
Stem cells and cellular differentiation mechanisms. Neurobiology. Behaviour and neurogenesis in adult brain. Transmission of brain signals. Biology of NO.
Organizer and member of the organizing committees of numerous scientific conferences. Member of the science board and advisor to a number of biotechnological companies.
A recipient of awards and grants from the US National Institutes of Health, US National Science Foundation, as well as some other private and public foundations in the USA and Russia.