Attraction of the leading scientists to Russian institutions of higher learning, research organizations of the governmental academies of sciences, and governmental research centers of the Russian Federation

Laboratory for Arrhythmogenesis Research

About the Laboratory

This laboratory was established as part of a scientific research project supported with a monetary grant awarded by the Government of the Russian Federation under a grant competition designed to provide governmental support to scientific research projects implemented under the supervision of the world's leading scientists at Russian institutions of higher learning (Resolution of the RF Government No.220 of April 9, 2010). 

Link to the official website

Grant Agreement No.:
14.Z50.31.0026

Name of the institution of higher learning:
A. N. Bakulev Scientific Center for Cardiovascular Surgery at Russian Academy of Medical Sciences

Fields of scientific research:
Fundamental Medicine

Project goal:
The goal of the project is to create one of the world's leading research centers specializing in cardiac arrhythmia*.

Proj objectives:

To investigate the fundamental mechanisms causing the development of cardiac arrhythmia and the factors accounting for sudden cardiac death, as well as to develop effective methods of their therapy and prevention.

Anticipated results: 

Fundamental research in the field of biomarkers, as well as genetic and cell technologies offering new therapeutic opportunities will become very important. Development of a system of monitoring of patients suffering from cardiac arrhythmia, diagnostic algorithms, as well as short-term and long-term therapy outcomes as compared to their various genotypic and phenotypic varieties will make it possible to lay down a solid foundation for further research.

Leading scientist

 

Full name: Danilov Sergey Mikhailovich

Link to the scientist's profile

Academic degree and title:
Doctor of Biology and Doctoral degree in Medicine, Professor

Job title:

Head of the Laboratory for Biology of angiotensin-converting enzyme (ACE) of the Anaesthesiology Research Center of the Illinois University (Chicago, USA), professor emeritus of the Department of Mathematics at the Blekinge Institute of Technology (Karskrona, Sweden).

Fields of scientific interests:

Fundamental medicine: pathophysiology, immunology, medical genetics, medical biochemistry. Biology of the angiotensin-converting enzyme (ACE)*.

Scientific recognition: 

The leading scientist has developed two new medical research areas: immunohistochemistry of the angiotensin-converting enzyme (ACE) and ACE conformational fingerprinting.
He initiated and conducted biochemical and immunological research of human ACE. To that end, he used a unique panel of monoclonal antibodies** to ACE.
He obtained and characterised 40 monoclonal antibodies to human ACE. He initiated multicenter research of human ACE in organs and tissues affected by various pathologies. He has published over 160 scientific works and obtained eight patents, including two international patents.

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