Laboratory for the Study of Cytokinesis
This laboratory was established as part of a scientific research project supported with a monetary grant awarded by the Government of the Russian Federation under a grant competition designed to provide governmental support to scientific research projects implemented under the supervision of the world's leading scientists at Russian institutions of higher learning (Resolution of the RF Government No.220 of April 9, 2010).
Grant Agreement No.:
Name of the institution of higher learning:
Institute of Molecular and Cell Biology, Siberian Branch of Russian Academy of Sciences
Fields of scientific research:
The project seeks to research the mechanism that accounts for the kinetochore-assisted growth of microtubules in drosophila*, as well as to put together a highly skilled group of scientists capable of performing advanced and world-class quality research projects in the field of cellular biology.
- To design new methods that could be used to analyze the kinetochore-assisted growth of microtubules in drosophila.
- To identify and describe the functions of the proteins required for the growth of kinetochore-assisted microtubules.
- To perform a functional analysis of evolutionary highly-conservative homologues of drosophila's mitosis-controlling proteins in a culture of human cells.
Anticipated results of the project:
The project will examine the ultrastructural organization of kinetochores and microtubules whose growth is assisted thereby. The project will identify new genes that encode the proteins required for the growth of kinetochore-assisted microtubules and establish functional interrelationships between those proteins. The project will describe evolutionary conservative proteins that control mitosis both in drosophila and in humans.
Leading scientist's full name: Gatti Maurizio
Link to the scientist's profile
Academic degree and title:
PhD, Professor in Genetics
Professor of the Department of Biology and Biotechnology, Institute of Molecular Biology and Pathology at National Research Council of Sapienza, University of Rome (Italy)
Fields of scientific interests:
Research of the structure of heterochromatin and chromosomes, mitosis and meiosis, as well as organization and evolution of telomeres.
Scientific recognition: The leading scientist discovered that the fertility factors located on drosophila's Y-chromosome are very large genes that form gigantic loops similar to lampbrush chromosomes that perform primarily the structural rather than protein-encoding function (1983–1988).
The leading scientist discovered and described drosophila with mutated chromosomal condensation and defective cytokinesis (1979–1989).
The leading scientist identified genes that prevent telomeres from merging (1997).
The leading scientist researched molecular mechanisms of cytokinesis and demonstrated that different types of drosophila cells containing centrosomes use different methods to assemble the cleavage spindle (1998–2013).
The research results obtained by the leading scientist, Maurizio Gatti, were used as the starting point for subsequent identification of numerous evolutionary-conservative genes that control mitosis in both drosophila and humans.
The leading scientist's work has helped discover the multiprotein complex "terminin" that specifically associates with the ends of the drosophila chromosomes and is a functional analogue of the multiprotein complex "shelterin" in mammals.