Laboratory for Control over Transcription and Replication
This laboratory was created in compliance with Resolution of the Government of the Russian Federation No.220 of April 9, 2010, "On measures designed to attract the world's leading scientists to Russian institutions of higher learning, research institutions of the governmental academies of sciences and governmental research centers of the Russian Federation".
Host institution of higher learning:
State educational institution of higher professional education "Moscow State University named after M. V. Lomonosov"
Scientific research area:
To research the mechanisms responsible for the copying of genetic and epigenetic information and to develop techniques that can be used to control these mechanisms.
Key project objectives:
1. To research transcription control mechanisms;
2. To develop new methods and approaches to therapy of various socially meaningful health conditions.
Anticipated project outputs:
The project will research transcription control mechanisms and help develop new generation medications using genetic engineering methods. This research is required to ensure ongoing development of Russia's pharmaceutical and biotechnological industry sectors, as well as to develop new methods and approaches to therapy of various socially meaningful health conditions.
Leading scientist's full name: Studitsky, Vassily Mikhailovich
Candidate of biological sciences
Professor at the department of pharmacology of the University of Medicine and Dentistry of New Jersey (USA); leading researcher at the faculty of biology at the Moscow State University.
Field of scientific interests:
1. Chromatin remodeling mechanism and histone code maintenance during transcription.
2. Enhancers and insulators action mechanisms and the role of elongation factors in the tumor process.
Key scientific achievements:
- The project helped develop new experimental systems that are used to analyze the mechanism of translation of information from DNA to RNA (transcription);
- The project scientists discovered new mechanisms of transcription of DNA-protein complexes (chromatin) using RNA polymerases 2 and 3;
- The project scientists discovered the action mechanism of chromatin-specific transcription factors and histone chaperones FACT, TFIIS and nucleolin;
- The project scientists discovered the mechanism of preservation of the epigenetic ("histone") code in the process of transcription;
- The project scientists discovered the mechanisms of distant interaction between remote DNA control segments (enhancers and promoters) on DNA and in chromatin;
- The project scientists published more than 50 articles on the project.