Apoptosis Mechanisms Research Laboratory (AMRL)
This laboratory was established as part of a scientific research project supported with a monetary grant awarded by the Government of the Russian Federation under a grant competition designed to provide governmental support to scientific research projects implemented under the supervision of the world's leading scientists at Russian institutions of higher learning, research institutions of the governmental academies of sciences and governmental research centers of the Russian Federation (Resolution of the RF Government No.220 of April 9, 2010).
Scientific research area:
Medical sciences and technologies
To research molecular mechanisms of apoptosis and other forms of cellular death, as well as the role of their disorders in various pathologies.
Key project objectives:
1. To research time-space coordination in activation of important enzymes involved in the development of apoptosis;
2. To research the role and importance of specific subcellular organelles in activation of important enzymes involved in the development of apoptosis;
3. To research the mechanisms responsible for enhancing the sensitivity of cancer cells to therapy by stimulating cellular death.
Anticipated project outputs:
1. The project will help develop new approaches to engineering of pharmaceuticals;
2. The project will develop a theoretical and practical course of study "Cellular death: theory and practice" designated for young scientists and researchers of the Moscow State University named after M. V. Lomonosov and other institutions of higher learning.
Leading scientist's full name: Zhivotovsky, Boris Davidovich
Academic degree and title:
Doctor of biological sciences, professor
Head of the Department of toxicology at the Karolinska Institute (Sweden) and Institute of Ecological Medicine (Sweden)
Field of scientific interests:
Research of the cellular death mechanisms and their role in enhancing the sensitivity of cancer cells to therapy.
- USSR State Prize recipient (1987);
- Ben Gurion University's Doros Foundation Prize, Israel (2006);
- R. Descartes Prize for outstanding achievements in the research of apoptosis mechanisms (2006);
- Europe's most frequently cited toxicologist prize (2009);
- President of the European Cell Death Organization (since 2009).