Attraction of the leading scientists to Russian institutions of higher learning, research organizations of the governmental academies of sciences, and governmental research centers of the Russian Federation

Laboratory for Non-Mendelian inheritance

About Laboratory

Grant Agreement No.: 14.Y26.31.0024
Project name: Non-Mendelian inheritance: conserved mechanisms of parent-of-origin effects
Name of the institution of higher learning: Novosibirsk State University
Fields of scientific research: Biology

Purpose is to elucidate, in concrete molecular and cellular terms, the volutionarilyconserved molecular mechanism of parent-of-origin effects in animals.

Leading scientist

 DR PRIM SINGH DN01 resize

Name:  Singh Prim


Academic degree and title: PhD
Job Title: Principal Investigator, School of Natural Sciences and Psychology, Liverpool John Moores University
Field of scientific interests: Gene expression, molecular biology, epigenetics, heterochromatin

Scientific recognition:
1984 - Bye-Fellowship Cambridge University
1986 - Biotechnology and Biological Sciences Research Council Research Fellow, UK Government

Scientific work of the leading scientist, his/her main scientific achievements:
Dr. Prim Singh is one of the leading researchers in the field of genetics.
1984-1985: Bye-Fellow of Magdalene College, Cambridge University, UK.
1988 - 1996: BBSRC Research Fellow, BBSRC Babraham Institute, Cambridge, UK.
1996-1999: Principal Investigator and subsequent Head of Chromatin Function Laboratory, BBSRC Babraham Institute, CAMBRIDGE, UK.
1999-2004: Principal Investigator and Head, Nuclear Reprogramming Laboratory,
BBSRC Roslin Institute, EDINBURGH, UK. .
2004-2008: Principal Investigator, Division of Tumor Biology, Research Center
Borstel, Parkallee 22, 23845-Borstel, GERMANY.
2008-2011: Principal Investigator, Division of Immuno-epigenetics, Research
Center Borstel, Parkallee 22, 23845-Borstel, GERMANY.
2011-2014: Principal Investigator, Fächereverbund Anatomie, Institut für Zell und
Neurobiologie, Charite-Universitätsmedizin,10117 Berlin, GERMANY.
2014-present: Principal Investigator, Natural Sciences

Newman, Andrew, Bessa, Paraskevi, Tarabykin, Victor and Singh, Prim, B. Activity-DEPendent Transposition 2017 Embo Reports

Helena Raurell-Vila, Laia Bosch-Presegue, Jessica Gonzalez-Nieto, Noriko Kane-Goldsmith, Carmen Casal, Jeremy P. Brown, Anna Marazuela-Duque, Prim B. Singh, Lourdes Serrano and Alejandro Vaquero An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions 2017 Epigenetics

Anna Mattout, Yair Aaronson, Sailaja BS, Edupuganti V Raghu Ram, Arigela Harikumar , Jan-Philipp Mallm, Kae Hwan Sim, Emmanuelle Supper, Prim B. Singh, Sze Siu Kwan,
Karsten Rippe and Eran Meshorer Heterochromatin Protein 1 beta (HP1 beta) has distinct  functions and distinct nuclear distribution in pluripotent versus differentiated cells 2015 Genome Biology

Maria Manukyan and Prim B. Singh Epigenome rejuvenation: HP1 beta mobility as a measure of pluripotent and senescent chromatin ground states 2014 Scientific Reports

Irina A. Maksakova, Preeti Goyal, Peter J. Thompson, Steven Jones, Prim B. Singh, Mohammad M. Karimi and Matthew C. Lorincz. Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells 2013 Epigenetics & Chromatin

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