Attraction of the leading scientists to Russian institutions of higher learning, research organizations of the governmental academies of sciences, and governmental research centers of the Russian Federation

Laboratory for innovation oncotherapy

About Laboratory

Grant Agreement No.: 14.W03.31.0029
Project name: A novel transglutaminase type2-based approach for therapy of hepatocellular carcinoma.
Name of the institution of higher learning: Institute of Cytology of the Russian Academy of Science
Fields of scientific research: Fundamental medicine

Гепатоклеточная карцинома (ГКК) занимает пятое место во всем мире среди онкологических заболеваний и является второй причиной смертности от рака. Ожидается, что количество пациентов, страдающих этим заболеванием, еще больше увеличится в ближайшие несколько лет из-за новых возникающих факторов риска. Трансглутаминаза типа 2 (TG2) представляет собой многофункциональный фермент, катализирующий посттрансляционные модификации белков как в ходе  Ca2+-зависимых, так и независимых реакций. Нарушение регуляции TG2 опосредует патогенез алкогольных и неалкогольных повреждений печени, а также приводит к формированию ГКК. Целью данного проекта является изучение роли TG2 и HSF1 в процессе развития этого злокачественного новообразования в клетках и модельных животных, а также оценка перспективности TГ2/HSF1 пути как потенциальной мишени для инновационной терапии гепатокарциномы.

Leading scientist

 Mauro Piacentin

Name:   Piacentini Mauro

 

Academic degree and title: PhD
Job Title: Full Professor of Cellular and Developmental Biology, University of Rome "Tor Vergata"
Field of scientific interests: immunology, biochemistry, molecular biology, cell biology

Scientific recognition:
2010 - Elected Chair, Gordon Conference, USA
2007 - JSPS award, Japanese Society for the Promotion of Science
2006 - “Descartes Award" for Collaborative Research in Cancer and AIDS, European Commission
2013 - Career Award, International Cell Death Society

Scientific work of the leading scientist, his/her main scientific achievements:
Prof. Mauro Piacentini has over 30 years experience working in the cell death/autophagy fields and their application to major human diseases with particular regards to cancer development. Among his major scientific accomplishments it is important to mention the discovery (Fimia et al. Nature 2007) and the characterization (Antonioli et al. Dev. Cell 2014 and Trends in Biochem. Sci. 2017) of the role of the gene Ambra1 in the regulation of autophagy in normal and neoplastic cells (Cianfanelli et al. Nat Cell Biol. 2015). Of note, it is the contribution of the Prof.
Piacentini's lab to the characterization of the molecular mechanisms at the basis of the "Immunogenic Cell Death" which plays a key role in the immune system-dependent eradication of tumors (Obeid et al. Nature Medicine 2007) as well as the role played by autophagy in melanomagenesis with particular regards to the BRAF mutation and ER stress induction (Corazzari et al. Cell Death Differ. 2015; Pagliarini et al. J. Cell Sci. 2015). Another important contribution (more than 100 pubblications) is the dissection of the role of the Transglutaminase type 2 (TG2) in apoptosis and more recently in the autophagic pathway in transformed cells (D'Eletto et al. Autophagy 2009 and Cell Death Differ. 2012). Prof Piacentini is the most cited scientist worldwide on TG2 (source ISI) and in 2015 he has been included among the 25 most cited authors in Cell Biology in Europe (source LabTimes).

Vescovo T, Romagnoli A, Perdomo AB, Corazzari M, Ciccosanti F, Alonzi T, Nardacci R, Ippolito G, Tripodi M, Garcia- Monzon C, Lo Iacono O, Piacentini M (*), Fimia GM.
Autophagy Protects Cells from HCV-Induced Defects in Lipid Metabolism. 2012 Gastroenterology

Corazzari M, Fimia GM, Piacentini M Dismantling the autophagic arsenal when it is time to die: Concerted AMBRA1 degradation by caspases and calpains. 2012 Autophagy

Fimia GM, Corazzari M, Antonioli M, Piacentini M. Ambra1 at the crossroad between autophagy and cell death. 2012 Oncogene

Nazio F, Strappazzon F, Antonioli M, Bielli P, Cianfanelli V, Bordi M, Gretzmeier C, Dengjel J, Piacentini M, Fimia GM, Cecconi F. mTOR inhibits autophagy by controlling ULK1
ubiquitylation, selfassociation and function through AMBRA1 and TRAF6. 2013 Nature Cell Biology

Corazzari M, Fimia GM, Lovat P, Piacentini M. Why is Autophagy Important for Melanoma? Molecular Mechanisms and Therapeutic Implications. 2013 Seminars in Cancer Biology

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